Ciclopirox

SKU: orb1308516

Description

Ciclopirox is a broad-spectrum synthetic antifungal agent that acts by chelating trivalent metal ions like Fe³⁺, disrupting essential fungal enzymes and cell wall integrity. Its additional anti-inflammatory properties arise from inhibiting 5-lipoxygenase and cyclooxygenase. This mechanism supports its research use in studying dermatophyte infections and inflammatory pathways in both in vitro and in vivo models.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 29342-05-0
• MW: 207.27
• Purity: 99.78% (May vary between batches)
• Formula: C₁₂H₁₇NO₂
• SMILES: ON1C(=CC(C)=CC1=O)C2CCCCC2
• Target: Antibacterial,ATPase,Ferroptosis,Antifungal,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.65 mM);DMSO:101 mg/mL (487.29 mM);Ethanol:20.7 mg/mL (99.87 mM)

Bioactivity

• In Vivo:
  Ciclopirox induces the activity of HIF-1-mediated reporter genes and the expression of endogenous HIF-1 target genes, including increased levels of mRNA expression, transcription, and vascular endothelial growth factor protein. It exerts a dose-dependent inhibitory effect on the growth of Candida albicans yeast and filamentous cells. Ciclopirox prevents mitochondrial damage induced by H2O2 by maintaining mitochondrial transmembrane potential. In adenocarcinoma SK-HEP-1 cells, Ciclopirox decreases MTT reduction (a marker of mitochondrial function) and completely blocks the release of lactate dehydrogenase (a marker of cell death) stimulated by hydrogen peroxide. In astrocytes treated with SIN-1 under glucose deprivation, Ciclopirox increases and maintains high levels of MTP, also preventing the depletion of adenosine triphosphate. Furthermore, Ciclopirox effectively inhibits the opening of mitochondrial permeability transition pores induced by hydrogen peroxide and protects astrocytes from peroxynitrite toxicity by mitigating mitochondrial dysfunction caused by nitrite.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ciclopirox, Autophagy, Bacterial, Fungal, Ferroptosis, Inhibitor, HOE296b, Na+/K+-ATPase, inhibit

Compound Identifiers

PubChem CID

2749