CIB-1476

SKU: orb2665362

Description

CIB-1476 is a selective caspase-1 inhibitor that blocks NLRP3 inflammasome signaling, thereby suppressing IL-1β maturation, NF-κB activation, and GSDMD-driven pyroptosis. It demonstrates potent and durable anti-inflammatory effects, effectively reducing joint swelling in murine arthritis models, making it a valuable tool for studying inflammasome-related pathways in vivo and in vitro.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction

Key Properties

• MW: 520.6
• Formula: C₂₈H₂₈N₂O₆S
• Target: Caspase,Pyroptosis,NOD-like Receptor (NLR),NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Pyroptosis,NOD-like Receptor (NLR),NF-κB