CI-898 HCl

SKU: orb1739176

Description

CI-898 HCl is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor, with binding enhanced by NADPH. It arrests the cell cycle at G1/S in L1210 leukemia cells, overcomes methotrexate resistance, and demonstrates synergistic activity with agents like doxorubicin in advanced P338 leukemia mouse models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1658520-97-8
• MW: 478.8
• Formula: C₁₉H₂₆Cl₃N₅O₃
• SMILES: Cl.Cl.Cl.COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC
• Target: Parasite,Others,DHFR,DNA/RNA Synthesis,Antibacterial,Antifolate,Antibiotic

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

45006154