Chrysotoxine

SKU: orb1218733

Description

Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.

Key Properties

• CAS Number: 156951-82-5
• MW: 318.36
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂O₅
• SMILES: COc(ccc(CCc(cc1OC)cc(OC)c1O)c1)c1OC
• Target: NF-κB

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: 460, H23 cells. Concentration: 0-20 μM. Incubation time: Overnight. Result: Significant decreased the p-Src and p-Akt expression in a dose-dependent manner instead of Src and Akt. Significantly reduced the down-stream stem cell transcription factor Sox2 as the decline of p-Src in H460 and H23 cells. Cell Viability Assay Cell line: 460, H23 cells. Concentration: 0, 1, 5, 10, 20 and 50 μM. Incubation time: 24 h. Result: Significantly reduced cell viability and increased H460 and H23 cells cell apoptosis at 50 μM with IC50s of 127.34 and 145.47 μM, respectively. Showed no cytotoxic effect on non-tumor cell lines at all tested concentrations. Cell Differentiation Assay Cell line: 460, H23 cells. Concentration: 5-20 μM. Incubation time: 72 h. Result: Decreased approximately 30%, 60%, 90%, and 95% of the H460 CSC spheroid size at day 7 with treated 1, 5, 10 and 20 μM Chrysotoxine, respectively. Decreased approximately 40%, 60%, 80%, and 92% of the H23 CSC spheroid size at day 7 with treated 1, 5, 10 and 20 μM Chrysotoxine, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol | Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-

Quick Database Links

Gene Symbol

NF-κB