ChREBPα/14-3-3 regulator-1

SKU: orb2945581

Description

Compound 43 is a selective molecular glue that stabilizes the ChREBP/14-3-3 interaction (EC50 = 3.8 µM). It protects pancreatic β-cells from glucolipotoxicity in vitro, preserving their function and highlighting its utility for type 2 diabetes and metabolic disease research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• MW: 389.263
• Formula: C₁₆H₁₅F₃NO₅P
• SMILES: C1=CC=C(C(=C1)OCC(=O)NCC(C2=CC(=CC=C2)F)(F)F)P(=O)(O)O
• Target: Molecular Glues

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171365647