CHPG hydrochloride

SKU: orb1710052

Description

CHPG hydrochloride is a potent and selective mGluR5 agonist. It is widely used in neuroscience research to investigate the receptor's role in synaptic plasticity, neuronal signaling, and related disorders, facilitating both in vitro and in vivo experimental studies.

Research Area

Neuroscience, Signal Transduction

Key Properties

• MW: 238.07
• Purity: 98.10% (May vary between batches)
• Formula: C₈H₉Cl₂NO₃
• SMILES: O=C(C(C1=CC(O)=CC=C1Cl)N)O.Cl
• Target: NF-κB,GluR,ERK
• Solubility: DMSO:30 mg/mL (126.01 mM)

Bioactivity

• In Vivo:
  In adult Sprague-Dawley male rats, injection of CHPG hydrochloride (250 nM) reduces significantly cerebral lesion volume by activation of the ERK and Akt signaling pathways.
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• In Vitro:
  After SO2 derivatives treatment, CHPG hydrochloride (10-500 µM) increases the cell viability and reduces the release of LDH. CHPG hydrochloride (0.5 mM) protects BV2 cells against SO2-induced apoptosis and increases the TSG-6 expression through the TSG-6/NF-κB pathway.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mGlu5, NF-κB, NFκB, NFkB, NF-kB, ERK, CHPG Hydrochloride, CHPG hydrochloride(170846-74-9 Free base)

Compound Identifiers

PubChem CID

169553362