Choline chloride

SKU: orb1309972

Description

Choline chloride, a key component of lecithin found in biological systems, serves as an acetylcholine precursor and a methyl donor. It is widely used in research on lipid metabolism, neurotransmission, and as a supplement in cell culture and animal studies to investigate metabolic and neurological functions.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 67-48-1
• MW: 139.63
• Purity: 99.91% (May vary between batches)
• Formula: C₅H₁₄ClNO
• SMILES: [Cl-].C[N+](C)(C)CCO
• Target: AChR,Endogenous Metabolite
• Solubility: H2O:26 mg/mL (186.21 mM);DMSO:50 mg/mL (358.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (23.63 mM);Ethanol:27 mg/mL (193.37 mM)

Bioactivity

• In Vivo:
  In cell culture, a deficiency of choline can lead to apoptosis, also known as programmed cell death.
• In Vitro:
  After oral administration of Choline chloride, clinical symptoms include restlessness, accelerated respiration, reduced activity, convulsions, wrinkled fur, unsteady gait, and respiratory distress. Choline chloride exhibits low acute oral toxicity. Some animals exhibit diarrhea following ingestion of Choline chloride. In one study, the autopsy revealed pulmonary inflammation in 30% of the rats in the high-dose group.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

nAChR, Nicotinic acetylcholine receptors, mAChR, inhibit, Hepacholine, Inhibitor, Endogenous Metabolite, Choline chloride, Choline Chloride, Choline, Biocolina, Biocoline, anti-inflammatory, analgesic, alpha7 nicotinic receptor

Compound Identifiers

PubChem CID

6209