Cholestyramine

SKU: orb1308842

Description

Cholestyramine resin is a bile acid sequestrant that binds to intestinal bile acids, preventing their reabsorption. This action promotes hepatic conversion of cholesterol into bile acids, depleting cellular cholesterol stores. It is widely used in research to study lipid metabolism, hypercholesterolemia, and atherosclerosis in both in vitro and in vivo models.

Key Properties

• CAS Number: 11041-12-6
• MW: 435.14
• Formula: C₂₇H₄₇ClN₂
• SMILES: N.[Cl-].CCC(C)C.CCC(CC(C)c1ccccc1)c1ccc(C[N+](C)(C)C)cc1
• Target: Others
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  GSPE treatment alone, and co-administration with Cholestyramine (Colestyramine), regulate BA, cholesterol and TG metabolism differently compare to Cholestyramine administration alone. Notably, GSPE decreases intestinal apical sodium-dependent bile acid transporter (Asbt) gene expression, while Cholestyramine significantly induces expression. Administration with GSPE or Cholestyramine robustly induces hepatic BA biosynthetic gene expression, especially cholesterol 7α-hydroxylase (Cyp7a1), compare to control, while co-administration further enhances expression. Treatment with Cholestyramine induces both intestinal and hepatic cholesterologenic gene expression, while co-administration with GSPE attenuates the Cholestyramine-inducing increase in the liver but not in the intestine. Cholestyramine also induces hepatic lipogenic gene expression, which is attenuated by co-administration with GSPE .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Colestyramine, Cholestyramine, Cholestyramine resin

Compound Identifiers

PubChem CID

137699107