CHNQD-01522

SKU: orb3210588

Description

CHNQD-01522 is a microtubule inhibitor that targets the colchicine binding site on β-tubulin. It disrupts microtubule polymerization and can evade P-glycoprotein transport in cancer cells. This compound inhibits cancer cell proliferation, prevents tumor cell colony formation, arrests the cell cycle at the G2/M phase, and induces apoptosis. CHNQD-01522 upregulates Bax and activates caspase-9 and caspase-3. In xenograft models of subcutaneous and orthotopic liver cancer, it exhibits antitumor activity and is applicable for hepatocellular carcinoma research.

Key Properties

• Target: Apoptosis,Caspase,Microtubule Associated,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,Microtubule Associated,Bcl-2 Family