CHNQD-01281

SKU: orb3173207

Description

CHNQD-01281 is a derivative of Brefeldin A and acts as an EGFR regulator. It exhibits potent antiproliferative activity against cancer cells, with IC50 values of 0.079 μM and 0.081 μM for T24 and J82 cells, respectively. CHNQD-01281 modulates both the EGFR/PI3K/AKT and EGFR/ERK pathways, influencing chemotactic effects on immune effector cells. It significantly inhibits tumor growth in T24 xenograft mouse models and extends survival in MB49 allograft mouse models by inducing cytotoxic T cell infiltration.

Key Properties

• CAS Number: 2762488-97-9
• MW: 411.5
• Formula: C₂₄H₂₉NO₅
• SMILES: O(C(/C=C/C=1C=CC=NC1)=O)[C@H]/2[C@]3([C@@](C[C@H](O)C3)(/C=C/CCC[C@H](C)OC(=O)\C=C2)[H])[H]
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR