CHM-1

SKU: orb1305859

Description

CHM-1 is a potent small molecule anticancer agent that induces apoptosis and exhibits antitumor activity in human hepatocellular carcinoma by activating Cdc2 kinase. It functions as a tubulin polymerization inhibitor, as demonstrated in both in vitro and in vivo studies, making it a valuable tool for cancer research, particularly in studying cell cycle disruption and cytoskeleton dynamics.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 154554-41-3
• MW: 283.25
• Purity: 99.84%
• Formula: C₁₆H₁₀FNO₃
• SMILES: O=C1C2=C(NC(=C1)C3=C(F)C=CC=C3)C=C4C(=C2)OCO4
• Target: Microtubule Associated,Apoptosis
• Solubility: H2O:< 7.08 mg/mL;DMSO:1.42 mg/mL (5.01 mM)

Bioactivity

• Target IC50:
  Apoptosis:0.75 μM (HA22T)
• In Vivo:
  In male severe combined immunodeficient mice, CHM-1 (10 mg/kg; i.p.) induced inhibition of HA22T tumor growth in a dose-dependent manner.
• In Vitro:
  CHM-1 (0-10 μM; 24 hours) significantly increased the binding of cyclin B1 to Cdc2 and induced change in expressed and phosphorylated status of G2-M regulators in HA22T cells. CHM-1 (0-100μM; 24 hours) induced significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells with an IC50 of 0.75 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cdc2, CHM 1, CHM1, CHM-1, carcinoma, Apoptosis, antimitotic, antitumor, Microtubule Associated, Microtubule/Tubulin, microtubule-destabilizing, MicrotubuleAssociated, NSC 656158, NSC656158, NSC-656158, inhibit, Inhibitor, hepatocellular, Tubulin polymerization

Compound Identifiers

PubChem CID

375860