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Chlorpropamide

SKU: orb1310562

Description

Chlorpropamide

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number94-20-2
MW276.74
Purity99.01% (May vary between batches)
FormulaC10H13ClN2O3S
SMILESO=C(NCCC)NS(=O)(=O)C1=CC=C(Cl)C=C1
TargetATPase,ABC Transporter
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.23 mM);Ethanol:51 mg/mL (184.29 mM);DMSO:55 mg/mL (198.74 mM)

Bioactivity

In Vivo
At a concentration of 0.2 mM, chlorpropamide elevated the levels of fructose-2,6-bisphosphate (F-2,6-P2) in isolated hepatocytes from rats. The compound operates through a cyclic AMP-independent mechanism, enhancing insulin's inhibitory effect on glucagon-stimulated gluconeogenesis. Chlorpropamide significantly increased glucose metabolism and total lipid content, irrespective of insulin deficiency (30%) or presence (31%).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Chlorpropamide, Diabinese, ABCC8, Inhibitor, inhibit, Na+/K+ ATPase, Sodium potassium pump

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Key Properties

No computed properties available.

Protocol Information

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1 g
$ 80.00
5 g
$ 110.00
10 g
$ 140.00
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