Chlorcyclizine

SKU: orb1297923

Description

CHLORCYCLIZINE is a small molecule with dual activity as an H1 antihistamine and a potent inhibitor of Hepatitis C Virus (HCV) cell entry. It is utilized in research to study HCV infection mechanisms and has demonstrated antiviral activity in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 82-93-9
• MW: 300.83
• Purity: 99.15% (May vary between batches)
• Formula: C₁₈H₂₁ClN₂
• SMILES: C(C1=CC=C(Cl)C=C1)(N2CCN(C)CC2)C3=CC=CC=C3
• Target: Histamine Receptor,HCV Protease
• Solubility: DMSO:125 mg/mL (415.52 mM)

Bioactivity

• In Vivo:
  Pregnant rats were administered 30, 60, or 90 mg/kg CHLORCYCLIZINE on Gestation Days 11 to 14. Fetal palate gene expression was also assessed after 90 mg/kg CHLORCYCLIZINE at 8, 15 and 30 hours post-dose on Gestation Day 14 using microarray and qRT-PCR. Rats in the 60- and 90-mg/kg groups exhibited adverse clinical signs and body weight loss. Rats in the 90-mg/kg group also demonstrated increases in late resorptions and decreases in fetal weight. Effects in the low-dose group were limited to decreases in body weight gain. Fetal assessment on Gestation Day 21 revealed that findings were limited to the 60- and 90-mg/kg groups, and included cleft palate (80% of litters for both groups), high arched palate, small nose, micrognathia, high domed head, digits shortened/absent and small limb. The fetal incidence of cleft palate was higher at 90 mg/kg, thus this dose was selected to assess palate gene expression. The altered genes associated with CHLORCYCLIZINE-induced cleft palate included Wnt5a, Bmp2, Bmp4, Fgf10, Fgfr2, Msx1, and Insig1 but the magnitude of the change was relatively small (1.5- to 2-fold).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chlorcyclizine, inhibit, Inhibitor, HCV, HCVProtease, HCV Protease, HistamineReceptor, Histamine Receptor, H1 receptor

Compound Identifiers

PubChem CID

2710