Chlorahololide D

SKU: orb1681393

Description

Chlorahololide D is a lindane-type sesquiterpene dimer and selective potassium channel blocker. It induces G2/M cell cycle arrest and apoptosis in MCF-7 breast cancer cells by elevating ROS and modulating Bcl-2/Bax/FAK pathways, demonstrating anti-proliferative, anti-migratory, and anti-angiogenic activity in vivo.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 943136-39-8
• MW: 676.75
• Purity: 98.43% (May vary between batches)
• Formula: C₃₈H₄₄O₁₁
• SMILES: C(\C(OC)=O)(/C)=C\1/[C@@]2([C@@]34[C@]([C@@]5(C)[C@]6([C@](C6)([C@](COC(/C(=C/C)/C)=O)(O)[C@@]5(CC3=C(COC(C)=O)C(=O)O4)[H])[H])[H])(CC7=C2[C@](C)([C@]8([C@@]7(C8)[H])[H])[C@@H](O)C1=O)[H])[H]
• Target: Potassium Channel,FAK,Bcl-2 Family

Bioactivity

• Target IC50:
  Rat dissociated hippocampal neurons:2.7±0.3μM|MCF-7 cells:6.7 μM|HepG2 cells:13.7 μM
• In Vivo:
  In MCF-7 xenograft zebrafish models, Chlorahololide D (2.5–10 μM) significantly reduced tumor fluorescence intensity and the number of metastatic foci. In transgenic zebrafish models, Chlorahololide D disrupted the formation of intersegmental vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs) in a dose-dependent manner (5–20 μM), indicating strong anti-angiogenic activity.
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• In Vitro:
  Chlorahololides D exhibited potent and selective potassium channel blocking activity on the delayed rectifier (IK) K+ current in rat dissociated hippocampal neurons, with the IC50 values of 2.7±0.3μM. Chlorahololide D exhibited potent cytotoxicity against MCF-7 breast cancer cells with an IC₅₀ of 6.7 μM, and moderate activity against HepG2 liver cancer cells (IC₅₀ = 13.7 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chlorahololide D

Compound Identifiers

PubChem CID

44207635