CHK1-IN-4 hydrochloride

SKU: orb1710065

Description

CHK1-IN-4 hydrochloride is a potent and selective checkpoint kinase 1 (Chk1) inhibitor that suppresses Chk1 phosphorylation in tumor cells. This compound demonstrates anti-tumor activity and is a valuable chemical probe for researching DNA damage response pathways in both cellular and animal models of cancer.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• MW: 480.75
• Purity: 99.29% (May vary between batches)
• Formula: C₁₈H₁₉BrClN₇O₂
• SMILES: Cl.COc1cc(Br)cc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
• Target: Chk
• Solubility: DMSO:5 mg/mL (10.4 mM)

Bioactivity

• In Vivo:
  CHK1-IN-4 hydrochloride (40 mg/kg, IV, twice a week) could enhance anti-tumor growth activity of CPT1 in the tumor model.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chk1, CHK1-IN-4 Hydrochloride, CHK1-IN-4 hydrochloride(2120398-41-4 Free base), 2120398-41-4, 2120398-41-4 Free base

Compound Identifiers

PubChem CID

171360044