CHK1-IN-3

SKU: orb1710067

Description

CHK1-IN-3 is a potent and selective checkpoint kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM. This small molecule is a valuable research tool for investigating DNA damage response pathways in vitro and has been utilized in studies exploring chemosensitization in cellular and preclinical cancer models.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2097252-39-4
• MW: 405.46
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₂₃N₉O
• SMILES: N(C)C=1C(=CN=C(NC=2C=C(O[C@@H]3CCCNC3)C(C#N)=NC2)N1)C4=CN(C)N=C4
• Target: Chk
• Solubility: DMSO:55 mg/mL (135.65 mM)

Bioactivity

• Target IC50:
  Chk1:0.4 nM
• In Vivo:
  In the Z-138 cell inoculated xenograft model, CHK1-IN-3 significantly suppresses the tumor growth as a single agent with bodyweight unaffected.
• In Vitro:
  CHK1-IN-3 displays a low affinity for hERG (IC50 > 40 µM). CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chk1, CHK1 IN 3, CHK1IN3, CHK-1-IN-3, CHK1-IN-3

Compound Identifiers

PubChem CID

138454800