CHK-IN-1

SKU: orb1708366

Description

CHK-IN-1 is a potent small molecule inhibitor targeting both checkpoint kinases CHK1 and CHK2. It exhibits antiproliferative effects and is utilized in cancer research to study DNA damage response pathways, with applications in both in vitro cellular assays and in vivo preclinical models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1278405-51-8
• MW: 407.89
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₁₉ClFN₅OS
• SMILES: N(C1=C2C(=C(C(N)=O)N=N1)SC(=C2)C3=CC(F)=CC=C3)[C@H]4CCCNC4.Cl
• Target: Chk

Bioactivity

• In Vitro:
  CHK-IN-1, as per research findings, has the capability to prevent the DNA damage repair mechanism from causing cell cycle arrest at the G2/M checkpoint.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chk2, CHK IN 1, Chk1, CHKIN1, CHK-IN-1

Compound Identifiers

PubChem CID

129626443