CHIR-99021 HCl

• Catalog Number: orb1704267
• Category: Small Molecules
• Description: CHIR-99021 HCl
• Purity: 98.07%
• MW: 501.8
• Biological Activity: CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/β-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3].
• CAS Number: [1797989-42-4]
• Formula: C₂₂H₁₉Cl₃N₈
• SMILES: Cl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl
• Storage: -20°C
• Note: For research use only