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CHIR-98014

SKU: orb1225512

Description

CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.

Images & Validation

Key Properties

CAS Number252935-94-7
MW486.3141
Purity>98% (HPLC)
FormulaC20H17Cl2N9O2
SMILESNC1=C(C=CC(NCCNC2=NC=C(N3C=CN=C3)C(=N2)C2=C(Cl)C=C(Cl)C=C2)=N1)[N+]([O-])=O
TargetGSK-3
SolubilityDMSO: 11 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CHIR98014 | CHIR 98014

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Protocol Information

CHIR-98014 (orb1225512)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

5 mg
$ 120.00
10 mg
$ 170.00
25 mg
$ 320.00
50 mg
$ 510.00
100 mg
$ 790.00
500 mg
$ 1,640.00