Chembridge-5861528

SKU: orb1305130

Description

Chembridge-5861528 is a selective TRPA1 channel antagonist, inhibiting calcium influx evoked by AITC and 4-HNE with IC50 values of 14.3 µM and 18.7 µM, respectively. This compound is a valuable research tool for studying TRPA1-mediated pathways in pain, inflammation, and respiratory disorders in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 332117-28-9
• MW: 369.42
• Purity: >99.99% (May vary between batches)
• Formula: C₁₉H₂₃N₅O₃
• SMILES: CCC(C)c1ccc(NC(=O)Cn2cnc3n(C)c(=O)n(C)c(=O)c23)cc1
• Target: TRP/TRPV Channel
• Solubility: DMSO:50 mg/mL (135.35 mM)

Bioactivity

• Target IC50:
  Ca2+ influx (AITC-evoked):14.3μM|Ca2+ influx (4-HNE-evoked):18.7 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antihypersensitivity, diabetes mellitus, Chembridge 5861528, Chembridge5861528, Chembridge-5861528, inhibit, neurogenic inflammation, Inhibitor, TCS 5861528, TCS-5861528, TCS5861528, Transient receptor potential channels, TRPChannel, TRPA1, TRP Channel, TRPV Channel, TRPVChannel

Compound Identifiers

PubChem CID

2873523