Chelidonine hydrochloride

SKU: orb1299919

Description

Chelidonine hydrochloride is a bioactive alkaloid isolated from Chelidonium majus. It exhibits a broad spectrum of pharmacological activities and is utilized in research areas such as cancer biology and neuropharmacology, with studies conducted in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 4312-31-6
• MW: 389.83
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₂₀ClNO₅
• SMILES: Cl.[H][C@]12[C@@H](O)Cc3cc4OCOc4cc3[C@@]1([H])N(C)Cc1c3OCOc3ccc21
• Target: Influenza Virus,Others,Apoptosis
• Solubility: DMSO:< 10 mM

Bioactivity

• In Vitro:
  Chelidonine significantly suppressed LPS-induced the production of NO and PGE2, as well as iNOS and COX-2 mRNA and protein expression. In addition, pro-inflammatory cytokines induced by LPS, such as TNFα and IL-6 were also attenuated by chelidonine. What's more, LPS-induced activation and degradation of IκBα followed by translocation of the p65 from the cytoplasm to the nucleus were attenuated by chelidonine. Furthermore, chelidonine even significantly inhibited TLR4 expression induced by LPS.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chelidonine Hydrochloride, Chelidonine hydrochloride

Compound Identifiers

PubChem CID

197809