Chebulinic acid

SKU: orb1296148

Description

Chebulinic acid is a multi-target small molecule that potently inhibits Mycobacterium tuberculosis DNA gyrase and also blocks SMAD-3 phosphorylation and H+ K+-ATPase activity. This makes it a valuable research tool for studies in bacteriology, oncology, and gastroenterology, applicable in both in vitro enzymatic assays and cellular research.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 18942-26-2
• MW: 956.68
• Purity: 99.71% (May vary between batches)
• Formula: C₄₁H₃₂O₂₇
• SMILES: OC1C2C(CC(O)=O)C(=O)OC3C(COC(=O)c4cc(O)c(O)c(O)c4)OC(OC(=O)c4cc(O)c(O)c(O)c4)C(OC(=O)c4cc(O)c(O)c(OC1=O)c24)C3OC(=O)c1cc(O)c(O)c(O)c1
• Target: Proton pump,DNA/RNA Synthesis,TGF-beta/Smad,Antibacterial,ATPase
• Solubility: DMSO:130 mg/mL (135.89 mM);H2O:<1 mg/mL (insoluble)

Bioactivity

• Target IC50:
  H+, K+-ATPase:IC50 : 65.01 μg/ml
• In Vivo:
  Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L .
• In Vitro:
  Chebulinic acid obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of Chebulinic acid inhibited HQ/Cu(II)-mediated double-strand breaks of genomic DNA .

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, H+/K+-ATPase, bacterial DNA gyrase, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, Chebulinic acid, Protonpump, Proton pump, Proton Pump, TGFb, TGF-b/Smad, TGF-beta/Smad, TGF-beta, TGFbeta, TGFbeta/Smad, TGFβ, TGF-β/Smad, Transforming growth factor beta, Smad, Smad3, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

250396