CHD1Li 6.11

SKU: orb1686992

Description

CHD1Li 6.11 is a potent, orally bioavailable small molecule inhibitor of oncogenic CHD1L (IC50: 3.3 μM). It demonstrates antitumor efficacy in vitro and significantly reduces tumor volume in vivo in colorectal cancer xenograft models derived from aggressive quasi-mesenchymal cells.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2716890-91-2
• MW: 472.4
• Purity: 98.03% (May vary between batches)
• Formula: C₂₁H₂₂BrN₅OS
• SMILES: Cc1cc(Nc2ccc(NC(=O)Cc3cc(Br)cs3)cc2)nc(n1)N1CCCC1
• Target: Others,DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.99 mM);DMSO:90 mg/mL (190.52 mM)

Bioactivity

• Target IC50:
  Catalytic CHD1L:3.3 µM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CHD1L

Compound Identifiers

PubChem CID

156868176