Ch282-5

SKU: orb2665535

Description

Ch282-5 is an orally bioavailable Bcl-2 inhibitor that induces mitochondria-dependent apoptosis in colorectal cancer cells by disrupting mitophagy and mTOR signaling, showing efficacy in both in vitro and in vivo models. It also enhances Oxaliplatin-induced autophagy and can mitigate thrombocytopenia, supporting its investigation in combination therapies.

Research Area

Cell Biology

Key Properties

• CAS Number: 65891-87-4
• MW: 804.75
• Formula: C₃₄H₃₄N₂Na₂O₁₄S₂
• SMILES: O=C1C2=C(C(C(C)=C1C(C(C3=C4C(C(C)C)=C(O)C(O)=C3C=NCCS(=O)([O-])=O)=O)=C(C)C4=O)=O)C(C(C)C)=C(O)C(O)=C2C=NCCS(=O)([O-])=O.[Na+].[Na+]
• Target: Apoptosis,Autophagy,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652567