CGS 15943

SKU: orb1219155

Description

CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively.

Key Properties

• CAS Number: 104615-18-1
• MW: 285.69
• Purity: >98% (HPLC)
• Formula: C₁₃H₈ClN₅O
• SMILES: C1=COC(=C1)C2=NN3C(=N2)C4=C(C=CC(=C4)Cl)N=C3N
• Target: AChR
• Solubility: DMSO:12.22 mg/mL (42.77 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells. Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM. Incubation time: 24 hours. Result: Inhibited growth of four distinct HCC cell lines. Western blot analysis. Cell line: HLF and Sk-Hep-1 cells. Concentration: 0 μM; 1 μM; 5 μM; 10 μM; 20 μM. Incubation time: 24 hours. Result: Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR