CGP 53353

SKU: orb1704624

Description

CGP 53353 (DAPH-7) is a selective protein kinase C (PKC) inhibitor, particularly targeting the PKCβII and PKCβI isoforms. This compound is a valuable research tool for investigating PKCβ-mediated signaling pathways in atherosclerosis research, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 145915-60-2
• MW: 365.33
• Purity: 98.11% (May vary between batches)
• Formula: C₂₀H₁₃F₂N₃O₂
• SMILES: Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(F)cc2)cc1
• Target: PKC
• Solubility: Ethanol:< 7.31 mg/mL;DMSO:50 mg/mL (136.86 mM)

Bioactivity

• Target IC50:
  PKCβII:0.41 mM|PKCβI:3.8 mM
• In Vitro:
  In A10 cells, CGP-53353 (DAPH-7) inhibits glucose-induced cell proliferation when administered at 1 μM for 48-96 hours. At a concentration of 1 μM for the initial 0-48 hours, CGP-53353 inhibits the glucose-induced increase and acceleration of DNA synthesis in A10 cells. It also blocks the glucose-induced increase in the percentage of S-phase cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DAPH-7, CGP 53353, CGP53353, CGP-53353, PKC

Compound Identifiers

PubChem CID

6711154