CGP 52432

SKU: orb1222716

Description

Cgp 52432 is a GABA-A receptor antagonist.

Key Properties

• CAS Number: 139667-74-6
• MW: 384.23
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₄Cl₂NO₄P
• SMILES: CCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O
• Target: GABAB
• Solubility: DMSO : 5 mg/mL 13.01 mM

Bioactivity

• In Vivo:
  CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i. v. , or 1 nmol/kg, i. c. v.) abolishes the suppressive effects of GABA (50 μmol/kg, i. v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
• In Vitro:
  CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cgp 52432 | Cgp52432 | Cgp52432

Quick Database Links

Gene Symbol

GABAB