CGP 37849

SKU: orb1685445

Description

CGP 37849

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 127910-31-0
• MW: 209.14
• Purity: 99.87%
• Formula: C₆H₁₂NO₅P
• SMILES: C\C(CP(O)(O)=O)=C/C(N)C(O)=O
• Target: NMDAR,iGluR
• Solubility: DMSO:Soluble;H2O:90 mg/mL (430.33 mM)

Bioactivity

• Target IC50:
  l-[3H]-glutamate:220 nM(Ki)|Seizures:21 mg/kg(ED50)|[3H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP):35 nM(Ki)
• In Vivo:
  In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurons induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate. Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED50 of 21 mg/kg.
• In Vitro:
  Within the hippocampal slice in vitro, CGP 37849 demonstrates reversible and selective antagonism against NMDA-induced increases in the firing rate of CA1 pyramidal cells. In the presence of a low Mg2+ level medium, concentrations of CGP 37849 up to 10 μM effectively inhibit burst firing evoked in CA1 neurons by stimulating Schaffer collateral-commissural fibers, while leaving the magnitude of the initial population spike unaffected.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NMDA receptor, iGluR, CGP 37849, CGP37849, CGP-37849

Compound Identifiers

PubChem CID

5950212