CGP 3466B maleate

SKU: orb1306197

Description

CGP 3466B maleate (Omigapil maleate) is an orally active inhibitor of GAPDH nitrosylation and apoptosis. It has been shown in preclinical studies to reduce Aβ-induced tau pathology and cognitive deficits in mouse models of Alzheimer's disease, and is also investigated for congenital muscular dystrophy research.

Research Area

Cell Biology

Key Properties

• CAS Number: 200189-97-5
• MW: 391.42
• Purity: 98.96% (May vary between batches)
• Formula: C₂₃H₂₁NO₅
• SMILES: OC(=O)\C=C/C(O)=O.CN(CC#C)CC1=Cc2ccccc2Oc2ccccc12
• Target: Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.11 mM);DMSO:60 mg/mL (153.29 mM)

Bioactivity

• In Vivo:
  Treatment with Omigapil (0.1 mg/kg) in 12-week-old dyW/ mag mice results in improved muscle regeneration and increased force .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Omigapil, Omigapil (Maleate), Omigapil Maleate, Omigapil maleate, Apoptosis inhibitor, CGP 3466B Maleate

Compound Identifiers

PubChem CID

9821821