CGK733

SKU: orb1307379

Description

CGK733

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 905973-89-9
• MW: 555.84
• Purity: 99.39%
• Formula: C₂₃H₁₈Cl₃FN₄O₃S
• SMILES: [O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F
• Target: ATM/ATR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.2 mM);DMSO:100 mg/mL (179.91 mM)

Bioactivity

• In Vivo:
  In senescent cells with halted proliferation, treatment with CGK733 leads to the disappearance of senescence-associated beta-galactosidase (SA-β-gal) activity, enablin the cells to proliferate. In aged MCF-7 cells, 24 hour treatment with CGK733 (30 μM) can induce cell death. furthermore , in various cancer cells, such as MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER-negative breast cancer cells, LnCap precursor cancer cells, and HCT116 colon cancer cells, CGK733 (0.6-40 μM) ha the capability to inhibit proliferation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, CGK 733, CGK733, CGK-733, ATM/ATR, ATM, ATM and RAD3 related, Ataxia telangiectasia mutated, ATR

Compound Identifiers

PubChem CID

6605258