CG347B

SKU: orb1218718

Description

CG347B is a selective inhibitor of HDAC6.

Key Properties

• CAS Number: 1598426-03-9
• MW: 283.33
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇N₃O₂
• SMILES: CCOC(c1cnc(NC2(CC2)c2ccccc2)nc1)=O
• Target: HDAC
• Solubility: DMSO:249 mg/mL (878.83 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  HtrA1 is identified as a Cisplatin (HY-17394, CDDP) resistance-related gene in NSCLC cells, while CG347B shows no effect on normalized mRNA expression or protein level of HtrA1 in NCI-H460 (CDDP-resistant) cells. CG347B (200 nM; 48 h) slightly rescues the Foxp3 expression inhibition induced by IL-4 (15 ng/mL), indicating a potential inhibition happens on histone deacetylation in naive CD4+ T cells from WT B6 mice cultured under Treg-polarizing conditions (for 1-3 d).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC