CFTR(inh)-172

SKU: orb1305605

Description

CFTR(inh)-172 is a potent and selective small-molecule inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, acting in a voltage-independent manner. It is widely used in both in vitro and in vivo research to investigate CFTR function in epithelial physiology, cystic fibrosis, and secretory diarrheas.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 307510-92-5
• MW: 409.4
• Purity: 99.94%
• Formula: C₁₈H₁₀F₃NO₃S₂
• SMILES: OC(=O)c1ccc(\C=C2/SC(=S)N(C2=O)c2cccc(c2)C(F)(F)F)cc1
• Target: Autophagy,CFTR
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.89 mM);DMSO:40.9 mg/mL (99.9 mM)

Bioactivity

• Target IC50:
  CFTR:300 nM(Ki)
• In Vivo:
  CFTRinh-172, a selective inhibitor of the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) channel, effectively eliminates Cl- (chloride) currents in the lacrimal gland acinar and duct cells of rabbits. It exhibits time- and dose-dependent inhibition of CFTR-mediated iodide transport and efficiently inhibits the activation of CFTR by various agonists or activators. Notably, CFTRinh-172 induces the production of ROS (Reactive Oxygen Species), mitochondrial depletion, and the activation of the NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) signaling pathway independently of its CFTR inhibitory action.
• In Vitro:
  Administering 20 μg of CFTRinh-172 over 6 hours fully abolished intestinal fluid secretion induced by Vibrio cholerae without affecting the growth of Vibrio cholerae within the body.
• Cell Research:
  Cell toxicity is assayed by the dihydrorhodamine method at 24 hours after cell incubation with 0–1,000 μM inhibitor. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Autophagy, Cystic fibrosis transmembrane conductance regulator, CFTRinh172, CFTRinh-172, CFTR Inhibitor-172, CFTR(inh) 172, CFTR(inh)172, CFTR(inh)-172, CFTRinh 172, CFTR

Compound Identifiers

PubChem CID

1554208