CFT7455

SKU: orb1301216

Description

CFT7455 (Cemsidomide) is a potent, orally bioavailable cereblon E3 ligase binder (Kd = 0.9 nM) that induces the degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). It is a research compound for studying hematological cancers, with demonstrated activity in both cellular assays and in vivo models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2504235-67-8
• MW: 469.53
• Purity: 99.59% (May vary between batches)
• Formula: C₂₈H₂₇N₃O₄
• SMILES: [H][C@@]1(CCC(=O)NC1=O)N1C(=O)c2cccc3c(Cc4ccc(CN5CCOCC5)cc4)ccc1c23
• Target: Molecular Glues,IKZF,Ligands for E3 Ligase
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.26 mM);DMSO:20 mg/mL (42.6 mM)

Bioactivity

• In Vivo:
  In mouse xenograft tumor models, CFT7455 (3 μg/kg-100 μg/kg) led to durable tumor regression and demonstrates dose-dependent efficacy.
• In Vitro:
  CFT7455 enables potent cell growth inhibition in both previously untreated NCIH929 multiple myeloma cell lines with an IC50 of 0.071 nM and NCIH929 cells made resistant to both lenalidomide and pomalidomide with an IC50 of 2.3 nM. CFT7455 promotes the degradation of >75% of steady state IKZF1 in multiple myeloma cells within 1.5 hours at 0.3 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-cancer agent, CFT7455, CFT-7455, CFT 7455, cereblon, cereblon (CRBN) E3 ligase, Cemsidomide, E3 ligase-recruiting Moiety, inhibit, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, orally active, Inhibitor, IKZF1, IKZF3 degrader

Compound Identifiers

PubChem CID

155207651