Tagarafdeg

SKU: orb2278978

Description

Tagarafdeg (CFT1946) is an orally bioavailable PROTAC degrader that selectively targets and degrades multiple mutant BRAF variants, including Class I (V600E), Class II (G469A), and Class III (G466V) mutations, as well as the p61 splice variant. It demonstrates high proteome selectivity, sparing wild-type BRAF and CRAF, and potently inhibits tumor cell proliferation in preclinical cancer research models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2882165-79-7
• MW: 958
• Purity: ＞99.99% (May vary between batches)
• Formula: C₄₅H₄₉F₂N₁₁O₉S
• SMILES: CN1C=2C(C(=N1)N3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC(=O)N5CCC6(CC5)C[C@H](CO6)N7C(=O)C=8C(N=C7)=CC=C(OC9=C(C#N)C(NS(N(CC)C)(=O)=O)=CC=C9F)C8)(O)CC4
• Target: Raf,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166168413