CFI-402257

SKU: orb1704839

Description

CFI-402257 is a potent and selective Mps1/TTK kinase inhibitor (Mps1 Ki = 0.09 nM). It is a valuable research tool for investigating hepatocellular carcinoma, with utility demonstrated in both in vitro cellular assays and in vivo tumor model studies.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1610759-22-2
• MW: 498.58
• Purity: 99.51% (May vary between batches)
• Formula: C₂₈H₃₀N₆O₃
• SMILES: N(C[C@H]1C[C@@](C)(O)C1)C=2N3C(=C(C=N3)C4=CC(C)=C(C(NC5CC5)=O)C=C4)N=C(OC=6C=CC=NC6)C2
• Target: Kinesin,Tyrosine Kinases
• Solubility: DMSO:37.7 mg/mL (75.61 mM)

Bioactivity

• Target IC50:
  Mps1:0.09 nM (Ki)|Mps1:6.5 nM (EC50)|TTK:0.1 nM (Ki)|TTK:1.7 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TTK, Mps1, CFI402257, CFI-402257, CFI 402257

Compound Identifiers

PubChem CID

118086034