Cetylpyridinium Chloride

SKU: orb1300767

Description

Cetylpyridinium chloride is a cationic quaternary ammonium antiseptic agent. It is widely used in research as a model antimicrobial compound for in vitro microbiological studies and in vivo investigations of oral cavity disinfection and biofilm disruption.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 123-03-5
• MW: 339.99
• Purity: 99.93% (May vary between batches)
• Formula: C₂₁H₃₈N·Cl
• SMILES: [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1
• Target: HBV,Antibacterial
• Solubility: DMSO:27.78 mg/mL (81.71 mM);Ethanol:63 mg/mL (185.3 mM);H2O:62 mg/mL (182.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.88 mM)

Bioactivity

• Target IC50:
  HBV capsid assembly:2.5 μM (IC50)
• In Vivo:
  Cetylpyridinium chloride increases the risk of severe allergic reactions, such as swelling of the mouth, face, lips or tongue, labored breathing, rashes, and hives. Ingesting high concentrations of cetylpyridinium chloride can lead to lung damage. Cetylpyridinium chloride is toxic if swallowed or inhaled.
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• In Vitro:
  Cetylpyridinium chloride (CPC) as active ingredient of antiseptic oral mouthrinses has a broad antimicrobial spectrum with a rapid bactericidal effect on gram-positive pathogens and a fungicide effect on yeasts in particular. Application of CPC at a concentration of 0.05% as a mouthrinse results in an immediate reduction in bacterial counts of 2.0 to 2.5 log steps (which is adequate to > 99%). This reverts to about 1 log step (= 90%) 1 h after application. The ability of CPC to inhibit plaque and thereby reduce gingivitis is assured. In comparison to chlorhexidine, CPC has a lower residual effect, and as a result a lesser effect against plaque and gingivitis. The efficacy of CPC against oropharyngeal candidiasis is assured. CPC mouthrinses can significantly reduce infectious aerosols in dental practice, thereby protecting both staff and the patient. The balance of intra-oral bacterial flora is not disturbed even in the case of relatively long-term use of CPC (up to six weeks).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cationic, Cetylpyridinium, Cetylpyridinium Chloride, Cetamium, assembly, anti-bacterial, ammonium, Capsid, Bacterial, Hexadecylpyridinium Chloride, Hepatitis B virus, HBV, inhibit, Inhibitor, mouthwashes, pesticides, quaternary, Pristacin, replication

Compound Identifiers

PubChem CID

31239