Cetrorelix Acetate

SKU: orb1301725

Description

Cetrorelix Acetate is a potent GnRH receptor antagonist (IC50 = 1.21 nM). It is widely used in research to inhibit gonadotropin secretion, facilitating studies in endocrinology, oncology, and reproductive biology in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 145672-81-7
• MW: 1491.11
• Purity: 98.00%
• Formula: C₇₀H₉₂ClN₁₇O₁₄.xC₂H₄O₂
• Target: GNRH Receptor
• Solubility: DMSO:50 mg/mL (33.53 mM)

Bioactivity

• Target IC50:
  GnRH:1.21 nM
• In Vivo:
  Cetrorelix inhibit the activation of hGnRHR and a downstream luciferase Reporter gene in murine LTK- cells b the GnRHR agonist [D-Trp6]GnRH IC50 = 1.2 nM). In vivo cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft mode.
• In Vitro:
  GnRH-I antagonist Cetrorelix inhibited growth of ES-2 cell line only at 1000 ng mL the incubation of ES-2 ovarian cancer cells in vitro with an GnRH-I antibody inhibited cell proliferation in a time and concentration dependent manner. GnRH-I may function as an autocrine growth factor in this ovarian cancer cell line.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

GnRHR, GNRH Receptor, GNRHReceptor, SB 75, SB75, SB-75

Compound Identifiers

PubChem CID

25078429