Cetaben

SKU: orb1308464

Description

Cetaben is a lipid-lowering agent that functions as a PPARα-independent peroxisome proliferator. It effectively lowers cholesterol and triglyceride levels and is noted for its non-fibrotic properties, making it a useful research tool for studying atherosclerosis and lipid metabolism in both in vitro and in vivo models.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 55986-43-1
• MW: 361.56
• Purity: 99.84% (May vary between batches)
• Formula: C₂₃H₃₉NO₂
• SMILES: CCCCCCCCCCCCCCCCNc1ccc(cc1)C(O)=O
• Target: Others
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Administration of 50-100 mg/kg Cetaben for over 10 days shows an obvious rise in the activities of peroxisomal enzymes in both the liver and kidney. However, the maximal effect is observed at 250 mg/kg.
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• In Vitro:
  The administration of 10 μM Cetaben for 24 hours induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After the administration of 10 μM Cetaben for 24 hours, cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells. After administration with 100 μM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

drug, Cetaben, cholesterol, exceptional, Inhibitor, hypolipidemic, inhibit, non-fibrate, peroxisome, PPARα, proliferator, triglycerides

Compound Identifiers

PubChem CID

47263