Cerulenin

SKU: orb1679008

Description

Cerulenin is a fungal metabolite and potent inhibitor of fatty acid synthase (FAS). It is widely used in research to study lipid metabolism, tumor biology, and metabolic disorders in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Key Properties

• CAS Number: 17397-89-6
• MW: 223.27
• Purity: >98%
• Formula: C₁₂H₁₇NO₃
• SMILES: [H][C@]1(O[C@]1([H])C(=O)CC\C=C\C\C=C\C)C(N)=O
• Target: Antibiotic
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).

Bioactivity

• In Vivo:
  The histological profile of ob/ob livers that received cerulenin treatment demonstrated a dramatic reduction in lipid content, which was dose and time dependent. Seven-day treatment of 60 mg/kg cerulenin daily or every other day demonstrated the greatest decrease of fat staining and in some areas of the liver, ORO staining was absent ( Fig. 3D–F ). Two-day treatment of 60 mg/kg cerulenin resulted in a modest reduction in fat content. In contrast, cerulenin given 30 mg/kg was less effective than 60 mg/kg doses, but its effect on fat content was still obvious except for 2-day treatment (data not shown).
• In Vitro:
  Cerulenin had a similar effect as StAR overexpression.StAR attenuated lipid synthesis and uptake as well as PA-induced inflammation and reduction in NO bioavailability in aortic endothelial cells. StAR can ameliorate endothelial dysfunction induced by PA via reducing the intracellular lipid levels.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Fungal, FAS, FattyAcidSynthase, Fatty Acid Synthase, Fatty Acid Synthase (FASN), Cerulenin, Antibiotic

Compound Identifiers

PubChem CID

5282054