Cernuumolide J

SKU: orb2665383

Description

Cernuumolide J (TMJ-105) is a potent JAK2/STAT3 signaling inhibitor with an IC50 of 1.79 µM against HEL leukemia cells, inducing G2/M arrest and apoptosis. Its anti-cancer activity, demonstrated in vitro, involves modulating MAPK pathways, making it a candidate for research in hematological malignancies and JAK/STAT-driven cancers.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2019163-02-9
• MW: 450.52
• Formula: C₂₄H₃₄O₈
• SMILES: O(C(C(C)C)=O)[C@@H]1[C@@]2([C@@]([C@H](OC(/C(=C\C)/C)=O)C(=O)[C@H](C)CCC[C@]1(C)O)(C(=C)C(=O)O2)[H])[H]
• Target: JNK,JAK,ERK,p38 MAPK,Apoptosis,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137631383