Cerivastatin sodium

SKU: orb1710087

Description

Cerivastatin sodium

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 143201-11-0
• MW: 481.53
• Purity: 99.67%
• Formula: C₂₆H₃₃FNNaO₅
• SMILES: [O-]C(C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(C(C)C)C(COC)=C1C2=CC=C(C=C2)F)=O.[Na+]
• Target: Opioid Receptor,HMG-CoA Reductase,Ferroptosis
• Solubility: DMSO:80 mg/mL (166.14 mM);H2O:80 mg/mL (166.14 mM)

Bioactivity

• Target IC50:
  HMG-CoA reductase:ki:1.3 nM/L
• In Vivo:
  Cerivastatin sodium is well absorbed, reaching maximum plasma concentration within 1-3 hours after oral administration. in the circulation, it is highly bound to plasma proteins (99.5%) and has an elimination half-life of 2-4 h. Cerivastatin sodium is metabolized primarily b the liver to three polar metabolites. Two of these metabolites are somewhat active, but much less so tha the prodrug, whil the third metabolite is inactive. Plasma concentration of these metabolites are much lower than those o the prodrug the metabolites are excreted primarily in the urine (20-25%) and feces (66-73%), with little detectable excretion o the unchanged prodrug.
• In Vitro:
  Cerivastatin sodium 5-50 ng mL treatment induces a dose-dependent decrease in cell proliferation of MDA-MB-231 cells (up to 40% Inhibition at 25 ng/mL), and 10-25 ng mL Cerivastatin sodium inhibits invasion of MDA-MB-231 cells through Matrigel. 25 ng mL Cerivastatin sodium delocalizes RhoA and Ras fro the membrane to the cytosol and induces morphological changes, and induces a marked increase in the level of p21Waf1/Cip1. This treatment increase the p21 transcript in MDA-MB-231 cells, and induces inactivation of NFκB, in a RhoA inhibition-dependent manner, resulting in a decrease in urokinase and metalloproteinase-9 expression, and concomitantly increases IκB.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

HMGCoA Reductase, HMG-CoA Reductase, HMG-CoA reductase, HMGCoAReductase, Ferroptosis, NOP receptor, OpioidReceptor, Opioid Receptor, Cerivastatin sodium, BAY W 6228 sodium

Compound Identifiers

PubChem CID

23663992