Ceranib1

SKU: orb1710090

Description

Ceranib1 is a cell-permeable ceramidase inhibitor that induces the accumulation of endogenous ceramides and reduces sphingosine and S1P levels, thereby suppressing ovarian cancer cell proliferation in vitro. This tool compound is used in sphingolipid metabolism research and oncology studies investigating ceramide-mediated apoptosis.

Key Properties

• CAS Number: 328076-61-5
• MW: 395.45
• Purity: 99.66% (May vary between batches)
• Formula: C₂₆H₂₁NO₃
• SMILES: COC1=CC=C(\C=C\C(=O)C2=C(C3=CC=CC=C3)C3=C(NC2=O)C=CC(C)=C3)C=C1
• Target: Others
• Solubility: DMSO:30 mg/mL (75.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.06 mM)

Bioactivity

• In Vitro:
  Ceranib1 produces a dose-dependent decrease in ceramidase activity, with 50% inhibition at 55 and 28 μM in SKOV3 cells. It prevents the hydrolysis of endogenous ceramide species, reducing intracellular sphingosine and S1P. Ceranib1 (10 nM-10 μM; 72 hours) exhibits antiproliferative activity for SKOV3 cells and does not cause significant acute cytotoxicity at concentrations up to those used in the ceramidase assay in SKOV3 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ceranib1, Ceranib-1, ceramidase

Compound Identifiers

PubChem CID

5761166