Ceranib-2

SKU: orb1309844

Description

Ceranib-2 is a cell-permeable ceramidase inhibitor (IC₅₀ = 28 µM in SKOV3 cells) that reduces sphingosine and S1P levels. This activity induces apoptosis and demonstrates anticancer effects in vitro, supporting its use in oncology research focused on sphingolipid metabolism.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1402830-75-4
• MW: 381.42
• Purity: 98.49% (May vary between batches)
• Formula: C₂₅H₁₉NO₃
• SMILES: COc1ccc(\C=C\C(=O)c2c(-c3ccccc3)c3ccccc3[nH]c2=O)cc1
• Target: LPL Receptor,S1P Receptor,Apoptosis
• Solubility: DMSO:60 mg/mL (157.31 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (6.55 mM)

Bioactivity

• Target IC50:
  Ceramidase:28 μM
• In Vivo:
  In female Balb/c mice, Ceranib-2 (20-50 mg/kg; i.p.) delays tumor growth without hematologic suppression in a syngeneic tumor model. Ceranib-2 (50 mg/kg; i.p.) increases the circulating levels, reaching a peak plasma concentration of approximately 40 μM at 2 hr.
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• In Vitro:
  In SKOV3 cells, Ceranib-2 (28 μM) decreases with 50% inhibition and induces the accumulation of multiple ceramide species. Ceranib-2 (10 nM-10 µM) inhibits cell proliferation and survival with an IC50 value of 0.73 μM. Ceranib-2 (0.75-1.5 µM) accumulates cells in the sub-G1. G2 and S phases of the cell cycle are concomitantly reduced in the number of cells in the G1 phase at the dose of 0.75 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S1P, S1P Receptor, S1PReceptor, 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one, Apoptosis, Ceramidase, Ceranib-2

Compound Identifiers

PubChem CID

72193861