Ceramides Mixture

SKU: orb1309845

Description

This endogenous Ceramides Mixture contains both hydroxy and non-hydroxy fatty acid ceramide species. It is widely used in research to study its roles in inducing cell cycle arrest, inhibiting proliferation, and modulating telomerase activity in various in vitro cellular models.

Research Area

Molecular Biology

Key Properties

• CAS Number: 100403-19-8
• MW: 581.967
• Purity: mixture
• Formula: C₃₆H₇₁NO₄
• SMILES: CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC
• Target: Telomerase
• Solubility: Chloroform:7.69 mg/mL;DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble);Ethanol:1 mg/mL;Methanol:< 1 mg/mL (insoluble)

Bioactivity

• In Vitro:
  Endogenous Ceramides inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of the c-Myc transcription factor in the A549 human lung adenocarcinoma cell line. The sustained generation of long-chain endogenous ceramide requires the biochemical recycling of the sphingosine backbone of C6-ceramide, which involves deacylation and reacylation of ceramide for the generation of endogenous long-chain ceramide, most likely by CoA-dependent ceramide synthase, which is inhibited by fumonisin B1. In A549 cells the generation of long-chain endogenous ceramide mediates the effects of exogenous C6-ceramide on growth inhibition, cell cycle arrest, and the modulation of telomerase activity .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

barrier, Ceramides Mixture, cell-cycle, CoA, c-Myc, Inhibitor, lipid, mRNA, inhibit, Golgi, Endogenous, Telomerase, transcription, permeability

Quick Database Links

Gene Symbol

Telomerase