Cephradine monohydrate

SKU: orb1707469

Description

Cephradine monohydrate is a broad-spectrum β-lactam cephalosporin antibiotic used in research for treating bacterial infections. It also acts as a TOPK inhibitor, with studies showing it can suppress UV-induced skin inflammation in experimental models, linking it to dermatological and cancer research applications.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 75975-70-1
• MW: 367.42
• Purity: 99.91% (May vary between batches)
• Formula: C₁₆H₂₁N₃O₅S
• SMILES: O=C1N2[C@@]([C@@H]1NC([C@H](N)C=3CC=CCC3)=O)(SCC(C)=C2C(O)=O)[H].O
• Target: Antibacterial,Antibiotic,TOPK

Bioactivity

• In Vivo:
  Methods: The dorsal skin of adult Babl/c mice was topically applied with Cephradine monohydrate (100 mg/kg), followed by SUV (100 KJ/m²) irradiation to investigate the effect of Cephradine monohydrate on SUV-induced skin inflammation in mice. Results: Cephradine monohydrate treatment significantly reduced the increase in epidermal thickness and immune cell infiltration in mouse skin after SUV (100 KJ/m²) irradiation. It also effectively inhibited the phosphorylation of p38, JNKs, and H2AX, as well as the secretion of IL-6 and TNF-α.
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• In Vitro:
  In HaCat and JB6 cells, Cephradine monohydrate (0.5, 1, and 2 mM, 2, 4, 6, and 12 hours) inhibited SUV-induced phosphorylation of p38, JNKs, and H2AX in a dose- and time-dependent manner, and suppressed the secretion of IL6 and TNF-α.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cefradine monohydrate, Cefradine, Cephradine, Cephradine Monohydrate, Bacterial

Compound Identifiers

PubChem CID

21124775