Cepharanthine

SKU: orb1310907

Description

Cepharanthine is a natural bisbenzylisoquinoline alkaloid with documented anti-inflammatory, antioxidant, and antitumor properties. It functions by inhibiting TNF-α-induced NF-κB activation, lipid peroxidation, platelet aggregation, and cytokine production. This compound is widely used in research areas including oncology, immunology, and inflammation, with applications in both cellular and animal model studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 481-49-2
• MW: 606.71
• Purity: 99.96%
• Formula: C₃₇H₃₈N₂O₆
• SMILES: COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c6OCOc6cc6CCN(C)[C@@H](Cc7ccc(Oc1c2)cc7)c56)cc34
• Target: Autophagy,SARS-CoV,TNF,HIV Protease,Parasite,Apoptosis,Cytochromes P450
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:9.3 mg/mL (15.33 mM);DMSO:242 mg/mL (398.87 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  CYP2E1:25.62 μM|CYP2C9:24.57 μM|CYP3A4:16.29 μM
• In Vivo:
  In SaOS2 cells, Cepharanthine (2.5–20 μmol/L) inhibits cell growth in a concentration- and time-dependent manner. At concentrations of 5–10 μmol/L, Cepharanthine markedly suppresses the expression of STAT3 target genes, including the anti-apoptotic gene Bcl-xL and cell cycle regulators c-Myc and cyclin D1. At 10 μmol/L, Cepharanthine induces a cell cycle arrest at the G1 phase and promotes apoptosis in SaOS2 cells. Furthermore, Cepharanthine (10–15 μmol/L) significantly reduces STAT3 expression in SAOS2 cells.
• In Vitro:
  In a xenograft model using SAOS2 cells in athymic mice, daily treatment with Cepharanthine (20 mg/kg) significantly reduced tumor volume and weight.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Autophagy, Cepharanthine, natural product, NSC623442, NSC-623442, Inhibitor, inhibit, NSC 623442, HIVProtease, HIV, HIV Protease, effective, proliferation, Stephania?cephalantha?Hayata, SARS coronavirus, SARS-CoV, TNF-α

Compound Identifiers

PubChem CID

10206