CEP-9722

SKU: orb1687843

Description

CEP-9722 is a potent, selective, and orally bioavailable dual inhibitor of PARP-1 and PARP-2. It demonstrates anticancer activity and is a valuable chemical tool for studying DNA damage response pathways in ovarian cancer research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 916574-83-9
• MW: 418.49
• Purity: 98.38% (May vary between batches)
• Formula: C₂₄H₂₆N₄O₃
• SMILES: O=C1C2=C3C(NC=4C=CC=C(OC)C43)=C5C(=C2C(=O)N1CN6CCN(C)CC6)CCC5
• Target: PARP

Bioactivity

• Target IC50:
  PARP2:6 nM|PARP1:20 nM
• In Vivo:
  In the RT4 xenograft model, CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; 5 days per week for 4 weeks) showed dose-dependent antitumor effects; 200 mg/kg/day was significantly superior to the control, while 100 mg/kg did not show significantly better efficacy than the control.
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• In Vitro:
  CEP-9722, the precursor drug of CEP-8983, is a selectively orally active inhibitor of PARP-1 and PARP-2, with IC50s of 20 nM and 6 nM for both, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CEP9722, CK-102, CK102

Compound Identifiers

PubChem CID

24780387