CEP-1347

SKU: orb2655879

Description

CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM; has weak inhibitory activity for Trk A and MLCK; promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade; inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells; elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.Parkinson Disease Phase 2 Discontinued.

Key Properties

• CAS Number: 156177-65-0
• MW: 615.76
• Purity: >98% (HPLC)
• Formula: C₃₃H₃₃N₃O₅S₂
• SMILES: O=C([C@]1(O)[C@@](O2)(C)N3C4=CC=C(CSCC)C=C4C5=C3C6=C(C7=CC(CSCC)=CC=C7N6[C@@]2([H])C1)C8=C5CNC8=O)OC
• Target: MLK

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KT-7515 | KT 7515 | CEP 1347

Quick Database Links

Gene Symbol

MLK