CeMMEC1

SKU: orb1302933

Description

CeMMEC1 is a dual-targeting small molecule inhibitor, potently inhibiting BRD4 and binding TAF1 with high affinity (IC50=0.9 µM). It serves as a valuable chemical probe for epigenetic and transcriptional research in oncology, enabling mechanistic studies in both cellular and biochemical assays.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 440662-09-9
• MW: 336.34
• Purity: 98.90%
• Formula: C₁₉H₁₆N₂O₄
• SMILES: Cn1cc(C(=O)Nc2ccc3OCCOc3c2)c2ccccc2c1=O
• Target: DNA/RNA Synthesis,Epigenetic Reader Domain,Carboxypeptidase
• Solubility: DMSO:5.63 mg/mL (16.74 mM)

Bioactivity

• Target IC50:
  TAF1:0.9 μM
• In Vitro:
  CeMMEC1 exhibits high affinity activity for the bromodomains of CREBBP, EP300, BRD9 and the second bromodomain of TAF1.
• Cell Research:
  REDS3 cells were treated with CeMMEC1(10 μM) incubating for 24 hours.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAF1, RNASynthesis, RNA Synthesis, Epigenetic Reader Domain, EpigeneticReaderDomain, CeMMEC1, CeMMEC 1, CeMMEC-1, BRD4, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis

Compound Identifiers

PubChem CID

24152379