Cefuroxime sodium

SKU: orb1309328

Description

Cefuroxime sodium

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 56238-63-2
• MW: 446.37
• Purity: 99.63%
• Formula: C₁₆H₁₅N₄NaO₈S
• SMILES: [Na+].N12[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/c2ccco2)SCC(=C1C(=O)[O-])COC(=O)N
• Target: Antibiotic,Antibacterial
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.48 mM);DMSO:55 mg/mL (123.22 mM)

Bioactivity

• In Vivo:
  The intravenous LD50 of cefuroxime sodium for mice is 10.4 g/kg the maximum dosage administered in Other acute toxicity tests is well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). however, when cefuroxime sodium is administered Subcutaneously (s.c.) or intramuscularly (i.m.) for 3 months to rats (100, 300 or 900 mg/kg/day) followed by a recovery period, and also for 6 months to rats and dogs (50, 150 or 450 mg/kg/day) and for 1 month to monkeys (150 or 450 mg/kg/day), there are no serious toxic effects in All tests. In rats large doses cause some increase in urine volume and electrolyte excretion, and slightly aggravates an age related nephropathy. Administration to rats intravenously (i.v.) for 1 month of up to 400 mg/kg/day has no toxic effects. In reproduction studies on mice and rabbits there are no adverse effects on fertility, organogenesis o the rearing of youn.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Bacterial, Biociclin, Anaptivan, Antibiotic, Cefuroxime, Cefuroxime sodium, Cefuroxime sodium salt, β-lactamase, Streptococcus pyogenes, S. faecalis

Compound Identifiers

PubChem CID

23670318